Immune system do not function properly may leads to several complications. Some issues are less pervasive, such as pollen allergy, while others have extensive genetic disorders that wipe out the function of entire set of immune cells. Immune system disorders may be temporary or permanent. Temporary immune disorder can be caused variety of sources that weaken the immune system. Common infections are influenza and mononucleosis can suppress the immune system.
When the immune cells are target of infections, severe immune suppression can occur. For example, HIV specifically infects the T cells, and their rejection allows for the secondary infections by the other pathogens. Patients receive chemotherapy, bone marrow transplantation, or using immunosuppressive drugs experience weakened immune systems until immune cells are restored. Pregnancy also suppresses the maternal immune system; it increases the susceptibility to infections by common microbes.
Primary immune deficiency diseases are inherited genetic disorders and it tends to cause chronic susceptibility to infections. Over the 150 PIDDs, and almost all are measured as rare troubling fewer than 200,000 people in the United States. They may result from altered immune signaling molecules or complete absenteeism of mature immune cells. X- Linked severe combined immunodeficiency is caused by a mutation in a signaling receptor gene, taking immune cells insensitive to multiple cytokines.
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